The 45-year-old is widely regarded as the greatest cruiserweight in professional wrestling history.
But he will leave it all behind after one final event according to the WWE.
Mysterio, real name Oscar Gutierrez, began his wrestling career at the age of 14 in his native Mexico.
He made his name at the World Championship Wrestling in 1995 where he popularised the lucha libre fighting style.
After WCW folded in 2001, Mysterio joined the WWE a year later where he came a huge star in the sport.
Since then he has gone on to win pretty much every title there is, including the tag-team, Intercontinental and most recently the United States strap.
Mysterio even stunned the WWE universe in 2006, when against the odds, he triumphed in the Royal Rumble.
But it was his comeback to Vince McMahon’s promotion in 2018 that shocked fans the most.
He had been away for three-years, thrilling spectators on the independent circuit again in his native Mexico and around the world.
The 619 specialist turned his hand at Lucha Underground, along with a small stint in New Japan Pro Wrestling.